Published in
Elsevier, Journal of Neuroimmunology, 1-2(220), p. 114-119, 2010
DOI: 10.1016/j.jneuroim.2010.01.004
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A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein
Journal article published in 2010 by
Jens Kuhle,
Axel Regeniter,
David Leppert,
Matthias Mehling,
Ludwig Kappos,
Raija L. P. Lindberg,
Axel Petzold 
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Abstract
The loss of neurological function is closely related to axonal damage. Neurofilament subunits are concentrated in neurons and axons and have emerged as promising biomarkers for neurodegeneration. Electrochemiluminescence (ECL) based assays are known to be of superior sensitivity and require less sample volume than conventional ELISAs.