ABSTRACT Coffee plantations installed at high altitudes and near forested areas have been highly infested with Anredera cordifolia. The objective of this work was to evaluate the effectiveness of different pre- and post-emergence herbicide treatments on A. cordifolia after mechanical mowing. A field experiment was carried out in a coffee plantation with natural infestation of A. cordifolia in a completely randomized design with a split-plot scheme and four replicates, in which the main plot an herbicides application and the subplot was the days after the initial application (DAI). The treatments were as follows: saflufenacil + glyphosate (70 + 960 g a.i. ha-1); chlorimuron + glyphosate (80 + 960 g a.i. ha-1); metsulfuron + glyphosate (6 + 960 g a.i. ha-1); flumioxazin + glyphosate (25 + 960 g a.i. ha-1), and glyphosate (960 g a.i. ha-1); with sequential application of glyphosate (960 g a.i. ha-1); glyphosate + indaziflam (960 + 75 g a.i. ha-1); indaziflam (75 g a.i. ha-1); and a control without herbicide application. Mechanical control, followed by the application of the treatments flumioxazin + glyphosate and metsulfuron + glyphosate in the first application and sequential application of indaziflam, proved to be effective. Control of this weed should be based on the removal of its plant residues from the field to reduce the regrowth and germination of aerial tubers.