In contemporary society, a notable trend of diminishing family sizes has led to an increasing number of elderly individuals living in solitude, often facing the end of life alone. This phenomenon underscores a critical challenge: addressing the pervasive loneliness experienced by many seniors. In response to this pressing issue, the concept of “cross-generational co-living” emerges as a potential solution. By exploring and implementing cross-generational co-living models, this research contributes to the development of more inclusive, supportive, and adaptable environments. The investigation involved an extensive field study and comprehensive data analysis of twenty-four instances of cross-generational co-living spaces in China and Italy. This analysis utilized space syntax as a fundamental theoretical framework, incorporating convex graphical topological relationship extraction and visibility graph analysis models. The outcomes of the study indicate that the configuration of cross-generational co-living spaces include spatial form, type, location, and the proportion of areas. Spaces arranged in a cluster form are most effective in promoting mutual communication. Spatial types and locations characterized by elevated integration values demonstrate a heightened potential for cross-generational communication. Space possessing a higher integration value typically correlates with a reduced ratio of area discreteness. These findings are instrumental in understanding how cultural and societal variances shape the design and utilization of cross-generational co-living spaces. Consequently, this study provides valuable guidelines for improving environments that are essential for advancing the principles of age-friendly design, which aims to enhance the quality of life for the elderly and foster a more harmonious and interconnected society across all generations.