Published in
American Society for Microbiology, Infection and Immunity, 7(91), 2023
DOI: 10.1128/iai.00168-23
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Intravenous BCG Vaccination of Diversity Outbred Mice Results in Moderately Enhanced Protection against Challenge with Mycobacterium tuberculosis Compared to Intradermal Vaccination
Journal article published in 2023 by
Sherry L. Kurtz 
,
Lara R. Mittereder,
Chelsea C. Lehman ,
Hamda Khan,
Victoria A. Gould,
Karen L. Elkins
,
Lara R. Mittereder,
Chelsea C. Lehman ,
Hamda Khan,
Victoria A. Gould,
Karen L. Elkins
This paper is made freely available by the publisher.
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Abstract
Tuberculosis is still the leading cause of death globally from any infectious disease, despite the widespread use of the live attenuated vaccine Bacille Calmette Guerin (BCG). While BCG has some efficacy against disseminated TB disease in children, protection wanes into adulthood resulting in over 1.8 million TB deaths per year.