Background. Magnetic resonance imaging (MRI) is one of the leading modalities for imaging of the musculoskeletal system. There are major problems in MRI of the hand, including lack of specialized coils and reliable fixation device for the hand, uncomfortable posture of the patient, motion artifacts, and small anatomical structures. These factors inevitably lead to incorrect interpretation of the study. Aim. To improve the quality of MRI of the hand by developing an approach to the study: selection of the coil and scanning protocol, as well as positioning and fixation of the patients hand. Materials and Methods. The positioning device was developed to prevent hand movements. Studies were performed using two types of coils. A comparative evaluation of the images was performed, as well as evaluation by the musculoskeletal radiologist. Results: А head coil is more appropriate when it is necessary to scan the entire hand, for example, in rheumatic diseases. A knee coil is more appropriate when it is necessary to study the small anatomical structures (including the wrist) due to a smaller field of view and higher resolution. Based on the obtained data, we formulated guidelines for MRI of the hand: selection of scanning parameters, sequences, and coils. We also suggested a specialized device for fixation of the patient's hand to prevent motion artifacts. Conclusion: There are a number of factors that directly affect qualitative MRI study of the hand: MRI safety, scanning parameters, fixation of the hand. The guidelines offered in this manuscript, as well as the use of the developed specialized fixation device can improve the quality of MRI of the hand.