Published in
American Society for Microbiology, Microbiology Spectrum, 3(11), 2023
DOI: 10.1128/spectrum.00141-23
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Role of the NaHCO <sub>3</sub> Transporter MpsABC in the NaHCO <sub>3</sub> –β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus
Journal article published in 2023 by
Sook-Ha Fan 
,
Richard A. Proctor,
Selvi C. Ersoy ,
Adhar C. Manna ,
Ambrose L. Cheung,
Friedrich Götz ,
Henry F. Chambers,
Arnold S. Bayer
,
Richard A. Proctor,
Selvi C. Ersoy ,
Adhar C. Manna ,
Ambrose L. Cheung,
Friedrich Götz ,
Henry F. Chambers,
Arnold S. Bayer
This paper is made freely available by the publisher.
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Abstract
MRSA infections are increasingly difficult to treat, due in part to their resistance to most β-lactam antibiotics. A novel and relatively common phenotype, termed NaHCO 3 responsiveness, has been identified in which MRSA strains show increased susceptibility in vitro and in vivo to β-lactams in the presence of NaHCO 3 .