Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(67), 2023
DOI: 10.1128/aac.00394-23
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Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus
Journal article published in 2023 by
Brenda Martínez-González,
Isabel Gallego,
Josep Gregori,
María Eugenia Soria,
Pilar Somovilla,
Ana Isabel de Ávila,
Carlos García-Crespo,
Antoni Durán-Pastor,
Carlos Briones 
,
Jordi Gómez,
Josep Quer,
Esteban Domingo ,
Celia Perales
,
Jordi Gómez,
Josep Quer,
Esteban Domingo ,
Celia Perales
This paper is made freely available by the publisher.
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Abstract
The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the present study, we report the mild mutagen activity of sofosbuvir (SOF) for hepatitis C virus (HCV).