AbstractPurposeDiffusion‐weighted (DW) imaging provides a useful clinical contrast, but is susceptible to motion‐induced dephasing caused by the application of strong diffusion gradients. Phase navigators are commonly used to resolve shot‐to‐shot motion‐induced phase in multishot reconstructions, but poor phase estimates result in signal dropout and Apparent Diffusion Coefficient (ADC) overestimation. These artifacts are prominent in the abdomen, a region prone to involuntary cardiac and respiratory motion. To improve the robustness of DW imaging in the abdomen, region‐based shot rejection schemes that selectively weight regions where the shot‐to‐shot phase is poorly estimated were evaluated.MethodsSpatially varying weights for each shot, reflecting both the accuracy of the estimated phase and the degree of subvoxel dephasing, were estimated from the phase navigator magnitude images. The weighting was integrated into a multishot reconstruction using different formulations and phase navigator resolutions and tested with different phase navigator resolutions in multishot DW‐echo Planar Imaging acquisitions of the liver and pancreas, using conventional monopolar and velocity‐compensated diffusion encoding. Reconstructed images and ADC estimates were compared qualitatively.ResultsThe proposed region‐based shot rejection reduces banding and signal dropout artifacts caused by physiological motion in the liver and pancreas. Shot rejection allows conventional monopolar diffusion encoding to achieve median ADCs in the pancreas comparable to motion‐compensated diffusion encoding, albeit with a greater spread of ADCs.ConclusionRegion‐based shot rejection is a linear reconstruction that improves the motion robustness of multi‐shot DWI and requires no sequence modifications.