AbstractPurposeAbdominal imaging is frequently performed with breath holds or respiratory triggering to reduce the effects of respiratory motion. Diffusion weighted sequences provide a useful clinical contrast but have prolonged scan times due to low signal‐to‐noise ratio (SNR), and cannot be completed in a single breath hold. Echo‐planar imaging (EPI) is the most commonly used trajectory for diffusion weighted imaging but it is susceptible to off‐resonance artifacts. A respiratory resolved, three‐dimensional (3D) diffusion prepared sequence that obtains distortionless diffusion weighted images during free‐breathing is presented. Techniques to address the myriad of challenges including: 3D shot‐to‐shot phase correction, respiratory binning, diffusion encoding during free‐breathing, and robustness to off‐resonance are described.MethodsA twice‐refocused, M1‐nulled diffusion preparation was combined with an RF‐spoiled gradient echo readout and respiratory resolved reconstruction to obtain free‐breathing diffusion weighted images in the abdomen. Cartesian sampling permits a sampling density that enables 3D shot‐to‐shot phase navigation and reduction of transient fat artifacts. Theoretical properties of a region‐based shot rejection are described. The region‐based shot rejection method was evaluated with free‐breathing (normal and exaggerated breathing), and respiratory triggering. The proposed sequence was compared in vivo with multishot DW‐EPI.ResultsThe proposed sequence exhibits no evident distortion in vivo when compared to multishot DW‐EPI, robustness to B0 and B1 field inhomogeneities, and robustness to motion from different respiratory patterns.ConclusionAcquisition of distortionless, diffusion weighted images is feasible during free‐breathing with a b‐value of 500 s/mm², scan time of 6 min, and a clinically viable reconstruction time.