AbstractQuantum utility is severely limited in superconducting quantum hardware until now by the modest number of qubits and the relatively high level of control and readout errors, due to the intentional coupling with the external environment required for manipulation and readout of the qubit states. Practical applications in the Noisy Intermediate Scale Quantum (NISQ) era rely on Quantum Error Mitigation (QEM) techniques, which are able to improve the accuracy of the expectation values of quantum observables by implementing classical post‐processing analysis from an ensemble of repeated noisy quantum circuit runs. In this work, a recent QEM technique that uses Fuzzy C‐Means (FCM) clustering to specifically identify measurement error patterns is focused. For the first time, a proof‐of‐principle validation of the technique on a two‐qubit register, obtained as a subset of a real NISQ five‐qubit superconducting quantum processor based on transmon qubits is reported. It is demonstrated that the FCM‐based QEM technique allows for reasonable improvement of the expectation values of single‐ and two‐qubit gates‐based quantum circuits, without necessarily invoking state‐of‐the‐art coherence, gate, and readout fidelities.