Imaging-based selection has become integral in guiding endovascular thrombectomy for large vessel occlusive stroke, driven by positive trial outcomes incorporating parenchymal and perfusion imaging criteria. While small-moderate core trials transformed acute reperfusion therapy, uncertainties persisted for large ischemic strokes. This was recently addressed in several treatment trials which demonstrated a benefit of endovascular thrombectomy in patients with large ischemic strokes, defined by parenchymal and/or perfusion imaging. Although individual trials suggest treatment benefits regardless of core size, patient-level meta-analyses are essential to clarify this relationship. Our aim was to summarize the imaging ramifications of the major endovascular thrombectomy trials of the past decade focusing on the interaction between the core and the treatment effect, to assist in the design of future meta-analyses. The core-treatment relationship that will be investigated in these meta-anlalyses will likely have major implications in our systems of care designs and in determining the utility of imaging-based selection.