This study uses a reduced-order two-dimensional (2-D) horizontal model to investigate the influence of the riverbank slope on the sinuosity-driven hyporheic exchange process along sloping alluvial riverbanks during a transient flood event. The deformed geometry method (DGM) is applied to quantify the displacement of the sediment–water interface (SWI) along the sloping riverbank during river stage fluctuation. This new modeling approach serves as the initial step focusing on the impact of the bank slope on the hyporheic exchange flux (HEF) and the residence time distribution (RTD) of pore water in the fluvial aquifer for a sinuosity-driven river corridor. Several controlling factors, including sinuosity, alluvial valley slope, river flow advective forcing and duration of flow, are incorporated into the model to investigate the effects of bank slope on aquifers of variable hydraulic transmissivity. Compared to simulations of a vertical riverbank, sloping riverbanks were found to increase the HEF. For sloping riverbanks, the hyporheic zone (HZ) encompasses a larger area and penetrated deeper into the alluvial aquifer, especially in aquifers with smaller transmissivity (i.e., due to increased hydraulic conductivity or reduced specific yield). Furthermore, consideration of sloping banks as compared to a vertical riverbank can lead to both underestimation and overestimation of the pore water travel time. The impact of bank slope on residence time was more pronounced during a flood event for high-transmissivity aquifer conditions, while it had a long-lasting influence after the flood event in lower-transmissivity aquifers. Consequently, the impact of bank slope decreases the travel time of water discharging into the river relative to base flow conditions. These findings highlight the need for (re)consideration of the importance of complex riverbank morphology conceptualization in numerical models when accounting for the HEF and RTD. The results have potential implications for river management and restoration and the management of river and groundwater pollution.