HighlightsDeveloping international registry that would unify different patient populations not represented in other registries and studies, and include patients with both manifested and subclinical atherosclerosis, is crucial for cardiovascular field. The collected data can be used in national guidelines, teaching and learning guides, and in clinical practice. AbstractMultifocal atherosclerosis (MFA) is one of the key issues in modern medicine. Several vascular beds are involved in the pathological process in every fifth patient with detected atherosclerosis. Moreover, patients with MFA have high risk of ischemic events, lower quality of life, shorter life expectancy and disability. “The Eurasian Association of Internal medicine” proposed to create a registry on real clinical practice in order to collect data on the frequency, detection methods, clinical course, risk factors and outcomes of patients with MFA in specialized centers in Russia and Commonwealth of Independent States (Republic of Kazakhstan, Republic of Uzbekistan, Republic of Belarus).