Published in
Oxford University Press, Inflammatory Bowel Diseases, 2024
DOI: 10.1093/ibd/izae023
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Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease
Journal article published in 2024 by
Josef Urrete,
Taniya Mitra,
Brigid S. Boland 
,
Kerri Bertrand,
Christina Chambers,
Jesús Rivera-Nieves
,
Kerri Bertrand,
Christina Chambers,
Jesús Rivera-Nieves
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Abstract
Lay Summary Despite a known role for α4β7 and MAdCAM-1 for the recruitment of antibody secreting cells to the lactating mammary gland, vedolizumab which targets integrin α4β7 did not lower breastmilk IgA in lactating mothers with IBD receiving the drug. It is likely that antibody secreting cells alternatively employ α4β1 to arrest on VCAM-1 also expressed by the lactating mammary gland.