Dissemin is shutting down on January 1st, 2025

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MDPI, Biomolecules, 4(13), p. 703, 2023

DOI: 10.3390/biom13040703

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Classification and Antigen Molecules of Autoimmune Bullous Diseases

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Autoimmune bullous diseases (AIBDs), which are a group of tissue-specific autoimmune diseases of the skin, present with various blistering lesions on the skin and mucous membranes, and show autoantibodies of IgG, IgA and IgM against epidermal cell surfaces and basement membrane zone. To date, AIBDs have been classified into a number of distinct subtypes by clinical and histopathological findings, and immunological characteristics. In addition, various biochemical and molecular biological studies have identified various novel autoantigens in AIBDs, which has resulted in proposals of new subtypes of AIBDs. In this article, we summarized various distinct AIBDs, and proposed the latest and most comprehensive classification of AIBDs with their autoantigen molecules.