Competency-based education (CBE) is a viable educational approach to close a training gap between ever-changing health challenges and pharmacy and pharmaceutical education curricula. However, the implementation of CBE into initial professional education and training (IPET) for pharmacists is slow. Thus, the development of a handbook to guide academics, educators, and practitioners in implementing CBE would be beneficial. This paper describes the process of developing a handbook to support educators in implementing CBE principles in IPET for pharmacists and pharmaceutical scientists. The project involves three phases: (1) a systematic review, (2) a global survey, and (3) the development of a handbook. The handbook provides guidance and a stepwise approach to implementing CBE in pharmacy curricula, which is particularly useful in resource-limited settings where curriculum overhaul using CBE principles might be challenging.