Published in
Royal Society of Chemistry, Chemical Science, 40(14), p. 11033-11039, 2023
DOI: 10.1039/d3sc03785a
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Catalytic olefin metathesis in blood
Journal article published in 2023 by
Igor Nasibullin 
,
Hiromasa Yoshioka ,
Akari Mukaimine,
Akiko Nakamura,
Yuriko Kusakari,
Tsung-Che Chang,
Katsunori Tanaka
,
Hiromasa Yoshioka ,
Akari Mukaimine,
Akiko Nakamura,
Yuriko Kusakari,
Tsung-Che Chang,
Katsunori Tanaka
This paper is made freely available by the publisher.
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Abstract
A Ru-based artificial metalloenzyme (ArM) at just 1–5 mol% could catalyze olefin metathesis in blood to construct various molecular scaffolds. The cancer-targeting ArM at a low dosage could elicit tumor growth inhibition by in vivo drug synthesis.