In a short time, single-cell platforms have become the norm in many fields of research, including multiple myeloma (MM). In fact, the large amounts of cellular heterogeneity in MM make single-cell platforms particularly attractive, as bulk assessments can miss valuable information about cellular subpopulations and cell-cell interactions. Single-cell platforms' decreasing cost and increasing accessibility, combined with breakthroughs in obtaining multi-omics data for the same cell and innovative computational programs for analyzing data, have allowed single-cell studies to make important insights into MM pathogenesis, yet there is still much to be done. In this review, we'll first focus on the types of single-cell profiling and the considerations for designing a single-cell profiling experiment. Then we'll discuss what we've learned from single-cell profiling about myeloma clonal evolution, transcriptional reprogramming and drug resistance and about the MM microenvironment during precursor and advanced disease.