In this work, we present theoretical predictions of a two-dimensional collinear antiferromagnetic semimetal, CrO, which exhibits a giant spin-split band structure, spin-momentum locked transport properties, and a high Néel temperature. Specifically, CrO features two pairs of spin-polarized anisotropic Weyl points at the Fermi level. By manipulating the position of these Weyl points with strain, we demonstrate that four different antiferromagnetic spintronic states with zero net magnetic moments can be achieved, including semimetals with two spin-polarized transport channels, half-semimetals, semiconductors with two spin-polarized transport channels, and half-semiconductors. The strain-induced semiconducting state also preserves the ultra-high carrier mobility of Weyl points, and the bandgap can be easily tuned. These findings offer a good avenue in spintronics without net magnetic moment or strong spin–orbit coupling and could lead to the development of antiferromagnetic materials for spintronic applications.