Background. The diagnosis of a chronic disease represents a turning point in patients’ lives, which inevitably marks them. The aim of this study was to analyze perceived stress levels among Crohn’ disease (CD) patients depending on sampling characteristics and several difficulties occurred in their daily life in order to better address stress management interventions to increase their quality of life as patients who should cohabitate with CD for all their lives. Materials and methods. An on-line, multicenter, observational, cross-sectional study was carried out through social Internet pages. Specifically, through the Facebook and Instagram groups belonging to the CD patients. Results. A total of 785 CD interviewers were achieved in this study, 597 were female and 188 were male. Significant higher stress perceived levels were assessed among females (p < 0.001) and CD interviewers who knew their disease until 10 years (p < 0.001). Higher levels in stress perceptions were reported in all the difficulties proposed, in which CD interviewers reported a quite level of difficulties occurred on them (p < 0.001). Conclusions. This study demonstrated that patients with Crohn’s disease live in a condition of high stress and that this condition implies changes in the quality of life with considerable difficulty.