Published in
American Society for Microbiology, Microbiology Spectrum, 4(11), 2023
DOI: 10.1128/spectrum.01277-23
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An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCC mec Cassette
Journal article published in 2023 by
Kasper Mikkelsen 
,
Janine Zara Bowring ,
Yong Kai Ng,
Frida Svanberg Frisinger,
Julie Kjærsgaard Maglegaard,
Qiuchun Li ,
Raphael N. Sieber ,
Andreas Petersen,
Paal Skytt Andersen,
Jakob T. Rostøl,
Nina Molin Høyland-Kroghsbo ,
Hanne Ingmer
,
Janine Zara Bowring ,
Yong Kai Ng,
Frida Svanberg Frisinger,
Julie Kjærsgaard Maglegaard,
Qiuchun Li ,
Raphael N. Sieber ,
Andreas Petersen,
Paal Skytt Andersen,
Jakob T. Rostøl,
Nina Molin Høyland-Kroghsbo ,
Hanne Ingmer
This paper is made freely available by the publisher.
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Abstract
CRISPR-Cas is an adaptive immune system protecting bacteria and archaea against mobile genetic elements such as phages. In strains of Staphylococcus aureus , CRISPR-Cas is rare, but when present, it is located within the SCC mec element, which encodes resistance to methicillin and other β-lactam antibiotics.