Published in
American Society for Microbiology, Journal of Virology, 5(97), 2023
DOI: 10.1128/jvi.00381-23
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HSV-1 Infection Induces a Downstream Shift of Promoter-Proximal Pausing for Host Genes
Journal article published in 2023 by
Elena Weiß 
,
Thomas Hennig ,
Pilar Graßl,
Lara Djakovic,
Adam W. Whisnant ,
Christopher S. Jürges,
Franziska Koller,
Michael Kluge,
Florian Erhard,
Lars Dölken,
Caroline C. Friedel
,
Thomas Hennig ,
Pilar Graßl,
Lara Djakovic,
Adam W. Whisnant ,
Christopher S. Jürges,
Franziska Koller,
Michael Kluge,
Florian Erhard,
Lars Dölken,
Caroline C. Friedel
This paper is made freely available by the publisher.
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Abstract
This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly capture the complex and unsuspected alterations in Pol II pausing occurring in HSV-1 infection.