Nanotechnology has been applied in healthcare to cure diseases, especially cancer. Cancer is one of the heterogenous diseases which lacks symptoms in the early stage thus has made it difficult to cure at a later stage. Despite early detection, effective treatment is regarded as one of the major solutions to cure cancer. Nanomaterials play a prominent role in enhancing or replacing conventional treatments with specific and less-toxic drug delivery or therapy. The requirement and properties of nanomaterials as well as their applications in cancer therapies are discussed in this chapter. Various types of nanoparticles are available on the bench side, but these nanoparticles may lack effectiveness to treat cancer using a single treatment mode. Hence, this chapter also explores the applications of various types of hybrid nanoparticles used in multiple therapies as they have shown more effective and safer outcomes for cancer patients. The combination of cancer therapies and their successes have been discussed in this chapter which is the cutting-edge applications of cancer treatment today.