Published in
American Physiological Society, AJP - Endocrinology and Metabolism, 5(325), p. E624-E637, 2023
DOI: 10.1152/ajpendo.00181.2023
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GCN2 is required to maintain core body temperature in mice during acute cold
Journal article published in 2023 by
Jordan L. Levy,
Emily T. Mirek 
,
Esther M. Rodriguez,
Brian Zalma,
Jeffrey Burns,
William O. Jonsson,
Harini Sampath ,
Kirk A. Staschke,
Ronald C. Wek,
Tracy G. Anthony
,
Esther M. Rodriguez,
Brian Zalma,
Jeffrey Burns,
William O. Jonsson,
Harini Sampath ,
Kirk A. Staschke,
Ronald C. Wek,
Tracy G. Anthony
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Abstract
This paper details the discovery that GCN2 activation is required in both male and female mice to maintain core body temperature during acute cold exposure. The results point to a novel role for GCN2 in supporting adaptive thermogenesis via amino acid transport and actomyosin mechanics in brown adipose tissue.