This study presents a comprehensive analysis of plastic waste accumulation in both terrestrial and aquatic environments in Can Tho city, Vietnam, a nation with high per capita plastic consumption and significant plastic waste discharge. Focusing on urban residential areas, riverside communities, suburbs, and rural regions, the research investigates the extent and impact of plastic waste in these diverse settings. Additionally, the study examines the accumulation of plastics at barriers, under bridges, and in the Hau River, identifying the predominance of single-use plastics and their environmental implications. The key findings indicate that the plastic waste leakage at land-based-source emission sites is substantial, with waste persisting for extended periods without effective clean-up. The study reveals a significant accumulation of plastics at barriers and bridge bases in aquatic environments, including along the river. The pollution level was observed to be more influenced by the quantity of waste rather than its mass per unit area, emphasizing the need for targeted waste reduction strategies. The study also identifies seven types of plastic, each associated with different sources of accumulation or settlement. This variety presents both challenges and opportunities for waste management and recycling. Significantly, the research underscores the potential of repurposing plastic waste into recycled products, aligning with the circular economy model. This approach not only extends the lifecycle of plastic products but also contributes to reducing plastic waste generation and minimizing the environmental impact. Overall, the findings highlight the urgent need for improved waste management practices in Vietnam, particularly in urban and riverside areas, and advocate for innovative recycling solutions to mitigate the environmental challenges posed by plastic pollution.