AbstractThe anodic methanol oxidation reaction (MOR) plays a crucial role in coupling with the cathodic hydrogen evolution reaction (HER) and enables the sustainable production of the high‐valued formate. Nickel‐based hydroxide (Ni(OH)₂) as MOR electrocatalyst has attracted enormous attention. However, the key factor determining the intrinsic catalytic activity remains unknown, which significantly hinders the further development of Ni(OH)₂ electrocatalyst. Here, we found that the electronic state within antibonding bands plays a decisive role in the whole MOR process. The onset potential depends on the deprotonation ability (Ni²⁺ to Ni³⁺), which was closely related to the band center of orbital. The closer of orbital to the Fermi level showed the stronger the deprotonation ability. Meanwhile, in the high potential region, the broadening of orbital would facilitate the electron transfer from methanol to catalysts (Ni³⁺ to Ni²⁺), further enhancing the catalytic properties. Our work for the first time clarifies the intrinsic relationship between electronic state and the MOR activities, which adds a new layer of understanding to the methanol electrooxidation research scene.