Published in
Royal Society of Chemistry, Chemical Science, 47(14), p. 13915-13923, 2023
DOI: 10.1039/d3sc03331g
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A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase
Journal article published in 2023 by
Teodors Pantelejevs 
,
Pedro Zuazua-Villar,
Oliwia Koczy ,
Andrew J. Counsell ,
Stephen J. Walsh ,
Naomi S. Robertson ,
David R. Spring ,
Jessica A. Downs,
Marko Hyvönen
,
Pedro Zuazua-Villar,
Oliwia Koczy ,
Andrew J. Counsell ,
Stephen J. Walsh ,
Naomi S. Robertson ,
David R. Spring ,
Jessica A. Downs,
Marko Hyvönen
This paper is made freely available by the publisher.
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Abstract
An approach for stapled peptide preparation in small scale using recombinant expression of peptide–protein fusions in bacteria. We use this approach to design binders of RAD51, characterise their interaction and demonstrate activity in cells.