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Royal Society of Chemistry, Chemical Science, 47(14), p. 13915-13923, 2023

DOI: 10.1039/d3sc03331g

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A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase

Journal article published in 2023 by Teodors Pantelejevs ORCID, Pedro Zuazua-Villar, Oliwia Koczy ORCID, Andrew J. Counsell ORCID, Stephen J. Walsh ORCID, Naomi S. Robertson ORCID, David R. Spring ORCID, Jessica A. Downs, Marko Hyvönen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

An approach for stapled peptide preparation in small scale using recombinant expression of peptide–protein fusions in bacteria. We use this approach to design binders of RAD51, characterise their interaction and demonstrate activity in cells.