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American Physiological Society, AJP - Endocrinology and Metabolism, 4(325), p. E303-E309, 2023

DOI: 10.1152/ajpendo.00134.2023

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Cross-species comparison of pregnancy-induced GDF15

Journal article published in 2023 by Anders Bue Klein, Pablo Ranea-Robles ORCID, Trine Sand Nicolaisen ORCID, Cláudia Gil, Kornelia Johann, Júlia Prats Quesada, Nina Pistolevij, Kathrine V. R. Hviid, Line Fich, Simone M. Offersen, Jørn Wulff Helge ORCID, Henriette Svarre Nielsen, Jaco Bakker ORCID, Maximilian Kleinert, Christoffer Clemmensen ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In the present study pregnancy-induced changes in circulating growth differentiation factor 15 (GDF15) in rodents, rhesus macaques, and humans are mapped. In sum, it is demonstrated that humans and macaques exhibit a tremendous increase in placental and circulating GDF15 during pregnancy. In contrast, GDF15 is negligibly increased in pregnant mice and rats, questioning a physiological role for GDF15 in pregnancy in rodents.