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MDPI, Viruses, 1(16), p. 150, 2024

DOI: 10.3390/v16010150

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Genomic Characterization of a Wild-Type Bovine alphaherpesvirus 1 (BoAHV-1) Strain Isolated in an Outbreak in Central Italy

Journal article published in 2024 by Stefano Petrini ORCID, Valentina Curini ORCID, Cecilia Righi ORCID, Cesare Cammà ORCID, Valeria Di Lollo, Elena Tinelli, Luana Fiorella Mincarelli ORCID, Elisabetta Rossi ORCID, Giulia Costantino ORCID, Barbara Secondini, Silvia Pirani ORCID, Monica Giammarioli ORCID, Francesco Feliziani ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Bovine alphaherpesvirus-1 (BoAHV-1) infection is common in cattle worldwide. However, information on the spread of BoAHV-1-circulating strains in Italy remains limited. In this study, we investigated an outbreak characterized by severe respiratory symptoms in a cattle herd (n = 30) located in Central Italy. BoAHV-1 was isolated from three cattle in a cell culture, which confirmed viral infection. Next, we characterized one (16453/07 TN) of the three isolates of BoAHV-1 using whole-genome sequencing. BLASTn and phylogenetic analysis revealed a nucleotide identity >99% with all BoAHV-1 strains belonging to subtype 1.1, highlighting the genetic stability of the virus. This study reports the first full genomic characterization of a BoAHV-1 isolate in Italy, enriching our understanding of the genetic characteristics of the circulating BoAHV-1 strain in Italy.