Abstract Calibration of pixel values is a fundamental step for accurate measurements in astronomical imaging. In astronomical jargon this is known as estimating zero-point magnitude. Here, we introduce a newly added script in GNU Astronomy Utilities (Gnuastro) version 0.20 for the zero-point magnitude estimation, named: astscript-zero-point. The script offers numerous features, such as the flexibility to use either image(s) or a catalog as the reference data set. Additionally, steps are parallelized to enhance efficiency for big data. Thanks to Gnuastro’s minimal dependencies, the script is both flexible and portable. The figures of this research note are reproducible with Maneage, on the Git commit e31dd15.