Published in
Royal Society of Chemistry, RSC Advances, 46(13), p. 32266-32275, 2023
DOI: 10.1039/d3ra03087c
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Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning
Journal article published in 2023 by
Nalinee Kongkaew 
,
Kowit Hengphasatporn ,
Yuwanda Injongkol,
Pitchayathida Mee-Udorn,
Liyi Shi,
Panupong Mahalapbutr,
Phornphimon Maitarad ,
Ryuhei Harada ,
Yasuteru Shigeta ,
Thanyada Rungrotmongkol ,
Alisa S. Vangnai
,
Kowit Hengphasatporn ,
Yuwanda Injongkol,
Pitchayathida Mee-Udorn,
Liyi Shi,
Panupong Mahalapbutr,
Phornphimon Maitarad ,
Ryuhei Harada ,
Yasuteru Shigeta ,
Thanyada Rungrotmongkol ,
Alisa S. Vangnai
This paper is made freely available by the publisher.
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Abstract
Design of novel 2-pralidoxime analogs by incorporating electron-donating groups onto its pyridinium core to enhance blood–brain barrier permeability and binding susceptibility toward acetylcholinesterase with paraoxon bound.