AbstractA variety of wearable technology for detecting human safety as well as environmental conditions have new research directions owing to 2D heterostructured transition metal dichalcogenides (TMDs), graphene (Gr), and reduced graphene‐oxide (rGrO). This in‐depth review article compiles the most recent and effective methods for ultrathin, large‐area flexible sensors with conformal adhesion to human skin that are essential for the development of wearable electronic skins. The results presented in this review aim to design flexible, comfortable wearable devices to monitor users’ continuous health conditions and to show the essential parameters (vital human activity signals such as heartbeat and pulse rate, expressions, and voice recognition) on smartphones in real‐time, allowing users to monitor their health issues in a convenient setting. When used to detect gases, higher selectivity biomolecules, and other organic and inorganic molecules, 2D TMDs can produce superior sensitivities and stability due to their unique and fascinating properties that result from the close interaction between the components. The understanding and control of excitonic effects and associated wearable applications in van der Waals heterostructures over a wide spectral response range is also encouraged. The review concludes by summarizing the present difficulties and opportunities.