Abstract We develop a novel approach to measure the dust attenuation properties of galaxies, including the dust opacity, the shape of the attenuation curve, and the strength of the 2175 Å absorption feature. From an observed spectrum, the method uses a model-independent approach to derive a relative attenuation curve with an absolute amplitude calibrated using NIR photometry. The dust-corrected spectrum is fitted with stellar population models to derive the dust-free model spectrum, which is compared with the observed SED/spectrum from NUV to NIR to determine the dust attenuation properties. We apply this method to investigate dust attenuation on kiloparsec scales using a sample of 134 galaxies with integral field spectroscopy from MaNGA, NIR imaging from 2MASS, and NUV imaging from Swift/UVOT. We find that the attenuation curve slope and the 2175 Å bump in both the optical and NUV span a wide range at kiloparsec scales. The slope is shallower at higher optical opacity, regardless of the specific star formation rate (sSFR), the minor-to-major axis ratio (b/a) of the galaxies, and the location of spaxels within individual galaxies. The 2175 Å bump presents a strong negative correlation with the sSFR, while the correlations with the optical opacity, b/a, and the locations within individual galaxies are all weak. All of these trends appear to be independent of the stellar mass of the galaxies. Our results support the scenario that the variation of the 2175 Å bump is driven predominantly by processes related to star formation, such as the destruction of small dust grains by UV radiation in star-forming regions.