Abstract Cattle farming is a major source of global food production and livelihoods that is being impacted by climate change. However, despite numerous studies reporting local-scale heat impacts, quantifying the global risk of heat stress to cattle from climate change remains challenging. We conducted a global synthesis of documented heat stress for cattle using 164 records to identify temperature-humidity conditions associated with decreased production and increased mortality, then projected how future greenhouse gas emissions and land-use decisions will limit or exacerbate heat stress, and mapped this globally. The median threshold for the onset of negative impacts on cattle was a temperature-humidity index of 68.8 (95% C.I.: 67.3–70.7). Currently, almost 80% of cattle globally are exposed to conditions exceeding this threshold for at least 30 days a year. For global warming above 4°C, heat stress of over 180 days per year emerges in temperate regions, and year-round heat stress expands across all tropical regions by 2100. Limiting global warming to 2°C, limits expansion of 180 days of heat stress to sub-tropical regions. In all scenarios, severity of heat stress increases most in tropical regions, reducing global milk yields. Future land-use decisions are an important driver of risk. Under a low environmental protection scenario (SSP3-RCP7.0), the greatest expansion of cattle farming is projected for tropical regions (especially Amazon, Congo Basin, and India), where heat stress is projected to increase the most. This would expose over 500 million more cattle in these regions to severe heat risk by 2090 compared to 2010. A less resource-intensive and higher environmental protection scenario (SSP1-RCP2.6) reduces heat risk for cattle by at least 50% in Asia, 63% in South America, and 84% in Africa. These results highlight how societal choices that expand cattle production in tropical forest regions are unsustainable, both worsening climate change and exposing hundreds of millions more cattle to large increases in severe, year-round heat stress.