This study analyzed the seasonality of biophysical parameters in the extreme years of precipitation and the relationship with the monthly precipitation of the state of Pernambuco at the regional level (Pernambuco) and homogeneous precipitation zones: zone 1—semiarid, zone 2—transition and zone 3—coastal. For this, the biophysical parameters at the monthly level in the extreme years, 2004 (wet) and 2012 (dry) were related to precipitation data of 45 rainfall stations. Using the Google Earth Engine platform, we calculate the biophysical parameters with MODIS products: Albedo, Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), Soil Adjusted Vegetation Index (SAVI), Normalized Difference Water Index (NDWI) and surface temperature (ST). Considering the most critical period, between September and December, of a wet year (2004) with a dry year (2012), there is an average reduction of 14% of vegetation indices (NDVI, EVI and SAVI), a 60% reduction in NDWI, an increase of 4% in albedo and 3% in surface temperature. For monitoring the water conditions of the state of Pernambuco, the most appropriate biophysical parameter is the NDWI index and surface temperature. In addition to NDWI, it is recommended to use EVI for semiarid areas (zone 1) and ST for coastal areas (Zones 2 and 3).