Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(67), 2023
DOI: 10.1128/aac.00266-23
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Frequent Emergence of Resistance Mutations Following Complex Intra-Host Genomic Dynamics in SARS-CoV-2 Patients Receiving Sotrovimab
Journal article published in 2023 by
Ana Álvarez-Uría,
Sofía de la Villa,
Rosalía Palomino-Cabrera,
Francisco Tejerina,
Gabriela Rodríguez Macias,
Andrea Molero-Salinas,
Darío García de Viedma 
,
Laura Pérez-Lago,
Luis Alcalá,
María Ferris,
Teresa Aldámiz,
Elena Bermúdez,
Cristina Veintimilla ,
Emilio Bouza,
Sergio Buenestado-Serrano
and other authors.
,
Laura Pérez-Lago,
Luis Alcalá,
María Ferris,
Teresa Aldámiz,
Elena Bermúdez,
Cristina Veintimilla ,
Emilio Bouza,
Sergio Buenestado-Serrano
and other authors.
This paper is made freely available by the publisher.
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Abstract
The emergence of the Omicron variant of SARS-CoV-2 represented a challenge to the treatment of COVID-19 using monoclonal antibodies. Only Sotrovimab maintained partial activity, allowing it to be used in high-risk patients infected with the Omicron variant.