Published in

American Physiological Society, American Journal of Physiology - Lung Cellular and Molecular Physiology, 3(326), p. L226-L238, 2024

DOI: 10.1152/ajplung.00421.2022

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Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Cell therapy is a potential treatment for cystic fibrosis (CF). Here, we model cell engraftment by injuring CF air–liquid interface cultures and delivering non-CF cells. Successful engraftment required severe epithelial injury. Intentionally injuring the lungs to this extent would be dangerous. However, naturally occurring events like viral infection induce similar epithelial damage. We found that viral preconditioning promoted the engraftment of cells primed for viral resistance leading to CFTR functional recovery to 20% of the wildtype.