American Physiological Society, American Journal of Physiology - Lung Cellular and Molecular Physiology, 3(326), p. L226-L238, 2024
DOI: 10.1152/ajplung.00421.2022
Full text: Unavailable
Cell therapy is a potential treatment for cystic fibrosis (CF). Here, we model cell engraftment by injuring CF air–liquid interface cultures and delivering non-CF cells. Successful engraftment required severe epithelial injury. Intentionally injuring the lungs to this extent would be dangerous. However, naturally occurring events like viral infection induce similar epithelial damage. We found that viral preconditioning promoted the engraftment of cells primed for viral resistance leading to CFTR functional recovery to 20% of the wildtype.