Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(67), 2023
DOI: 10.1128/aac.00304-23
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Iohexol-Measured Glomerular Filtration Rate and Urinary Biomarker Changes between Vancomycin and Vancomycin Plus Piperacillin-Tazobactam in a Translational Rat Model
Journal article published in 2023 by
Jack Chang,
Paul R. Yarnold,
Gwendolyn M. Pais 
,
Sylwia Marianski,
Kimberly Valdez,
Emily Lesnicki,
Erin F. Barreto ,
Nathaniel J. Rhodes,
Marc H. Scheetz
,
Sylwia Marianski,
Kimberly Valdez,
Emily Lesnicki,
Erin F. Barreto ,
Nathaniel J. Rhodes,
Marc H. Scheetz
This paper is made freely available by the publisher.
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Abstract
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding.