In psychological theories, difficulties of affect regulation, defined as alexithymia, are correlated with asthma but the association between alexithymia, asthma and quality of life has not been explained yet. The aim of the study was to: 1) determine the prevalence of alexithymia in patients with asthma, 2) evaluate the associations between the quality of life and the levels of alexithymia. Methods: Alexithymia was assessed with the TAS- 20 (Toronto Alexithymia Scale). The prevalence of this disorder in patients with asthma was compared to that in healthy subjects. Quality of life was evaluated with: AQLQ by Juniper for asthmatics. The associations among alexithymia, and the quality of life were estimated by data analysis. The data were analyzed using Pearson correlations, t-Student test. A p value ≤ 0.05 was required for statistical significance. Results: Fifty healthy people and fifty one asthmatic outpatients of Military Institute of Medicine in Warsaw, Poland participated in the study. Twenty percent of asthmatics and only four percent of healthy people reported high alexithymia scores. A higher alexithymia score was associated with worse quality of life. Conclusions: The prevalence of alexithymia is higher in patients with asthma. The coexistence of asthma and alexithymia is associated with deterioration of patient's quality of life.