Background: The aim of the study was to clinically evaluate, as well as analyse the direct costs of treating patients hospitalised due to adverse skin reactions related to antibiotics use at the Department of Dermatology of the Military Institute of Medicine, Ministry of Defence in Warsaw, during the years 2002-2012. Method: The study was carried out in a retrospective way on a group of 164 adult patients due to adverse skin drug reactions. The analysis was based on data from patient medical records and medical orders. Results: The most common drugs that caused adverse skin reactions in the examined population between the 2002-2012 were antibiotics with 75 cases, in 39 cases non-steroidal anti-inflammatory drugs (NSAIDs), and in the case of paracetamol 6, in 44 cases other drugs. Amoxicillin was the most common described antibiotic (25.33%). It has been estimated that patient hospitalisation at the Department of Dermatology for adverse skin drug reaction generated costs averaging to an amount of 2784 PLN (662 EUR) per patient. Conclusions: The most frequent form of drug-induced skin reactions, diagnosed in the study group, was the maculopapular rash - (52%). The most common drugs that caused skin lesions were antibiotics. Amoxicillin was the most common described antibiotic (25.33%). The largest average cost have been incurred due to clindamycin - 1059.91 PLN (252 EUR) and to amoxicillin - 1029.56 PLN (245 EUR). Following our analysis, treatment of skin adverse drug effects caused by antibiotics generates significant costs.