Published in
Royal Society of Chemistry, Chemical Science, 42(14), p. 11638-11646, 2023
DOI: 10.1039/d3sc04169g
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Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library
Journal article published in 2023 by
Tessa Keenan 
,
Natasha E. Hatton,
Jack Porter,
Jean-Baptiste Vendeville ,
David E. Wheatley ,
Mattia Ghirardello,
Alice J. C. Wahart ,
Sanaz Ahmadipour,
Julia Walton ,
M. Carmen Galan ,
Bruno Linclau,
Gavin J. Miller ,
Martin A. Fascione
,
Natasha E. Hatton,
Jack Porter,
Jean-Baptiste Vendeville ,
David E. Wheatley ,
Mattia Ghirardello,
Alice J. C. Wahart ,
Sanaz Ahmadipour,
Julia Walton ,
M. Carmen Galan ,
Bruno Linclau,
Gavin J. Miller ,
Martin A. Fascione
This paper is made freely available by the publisher.
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Abstract
A carbohydrate phosphorylase is utilised in the synthesis of unnatural Manβ1,4-GlcNAc and longer β-mannan like glycans, including formation of phosphorolysis-stable thioglycoside linkages via novel "reverse thiophosphorylase" enzymatic activity.