Immunoglobulins are a central component of humoral immunity and their serum concentrations are routinely determined in clinical practice because they provide key information on the humoral immune status. In a single centre prospective design study, we evaluated IgA, IgE, IgG, and IgM serum concentrations in patients with histologically confirmed acute appendicitis (study group, N=54) and compared it to the control group (N=69), patients submitted to appendectomy, but with normal histological findings, patients submitted to day case surgery and healthy volunteers. The serum concentrations of immunoglobulins were normal in all cases, except for IgE, that were elevated in both the study (20%) and control (21 %) groups (p= 0.609). These values are in good agreement with the prevalence of allergies in the general population. Our study is the first to address specifically the acute appendicitis Immunoglobulins humoral immune response in the English literature. We showed that acute appendicitis does not elicit a specific humoral immune response.