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Wiley, Chemistry and Biodiversity, 2024

DOI: 10.1002/cbdv.202400491

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In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p‐Coumaric Acid Prenylated Derivatives

Journal article published in 2024 by Tatiana M. Vieira ORCID, Júlia G. Barco ORCID, Lucas A. L. Paula ORCID, Paulo C. A. Felix, Jairo K. Bastos ORCID, Lizandra G. Magalhães ORCID, Antônio E. M. Crotti ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractWe have evaluated eight p‐coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)‐3,4‐diprenyl‐4‐isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92 μM) and S. mansoni (IC50=64.25 μM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p‐coumaric acid prenylated derivatives.