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American Physiological Society, American Journal of Physiology - Renal Physiology, 1(325), p. F38-F49, 2023

DOI: 10.1152/ajprenal.00425.2021

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A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature

Journal article published in 2023 by Scott S. Wildman, Kadeshia Dunn, Justin P. Van Beusecum ORCID, Edward W. Inscho, Stephen Kelley, Rebecca J. Lilley ORCID, Anthony K. Cook, Kirsti D. Taylor ORCID, Claire M. Peppiatt-Wildman ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Functional data here offer novel insight into the vasoactive activity of the renal GABA/glutamate system. These data show that activation of endogenous GABA and glutamate receptors in the kidney significantly alters microvessel diameter. Furthermore, the results show that these antiepileptic drugs are as potentially challenging to the kidney as nonsteroidal anti-inflammatory drugs.