American Physiological Society, American Journal of Physiology - Lung Cellular and Molecular Physiology, 5(325), p. L604-L616, 2023
DOI: 10.1152/ajplung.00441.2022
Full text: Unavailable
This study investigates the signaling pathways that mediate induction of BATF2 expression downstream of TLR4 and also the impact of BATF2 on the host defense against pulmonary Kp infection. We demonstrate that Kp-induced upregulation of BATF2 in macrophages requires TRIF and type I IFN signaling. We also show that BATF2 enhances Kp-induced macrophage cytokine responses and that BATF2 contributes to the early host defense against pulmonary Kp infection.