AbstractRheumatoid arthritis (RA) is a serious chronic disease that affects daily functioning and quality of life. Two studies were conducted to analyze the role of cognitive variables (namely cognitive appraisals and illness-related beliefs) in adaptation to life with chronic disease. A total of 150 people with rheumatoid arthritis (47 men and 103 women) were assessed both stationary (N = 69) and online (N = 81). The results of study 1 indicate that cognitive appraisals explain a greater percentage of variance than coping strategies with regard to the severity of depressive symptoms and the level of acceptance of living with the disease. In turn, the second study found that social support mediates the relationship between selected cognitive appraisals (loss, challenge and value) and anxiety. The latent profile analysis showed that the subgroups distinguished according to the illness-related beliefs levels differed in cognitive appraisals, but do not in the level of anxiety. The results indicate that cognitive appraisals, in line with theoretical assumptions, seem to be the key psychological factor determining the level of adaptation to life with rheumatoid arthritis. Social resources mediate the relationship between selected cognitive appraisals and anxiety. Cognitive appraisals are modeled through illness-related beliefs, which, in turn, can be modified, e.g. as part of psychological intervention.