Dissemin is shutting down on January 1st, 2025

Published in

Blood Cancer Discovery, 2(5), p. 86-89, 2024

DOI: 10.1158/2643-3230.bcd-23-0212

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Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges

Journal article published in 2024 by Nicholas J. Haradhvala ORCID, Marcela V. Maus ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Summary: Single-cell RNA sequencing has emerged as a powerful technique to understand the molecular features of chimeric antigen receptor (CAR) T cells that associate with clinical outcomes. Here we discuss the common themes that have emerged from across single-cell studies of CAR T-cell therapy, and summarize the challenges in interpreting this complex data type.