The performance of male soccer players (MSPs) depends on multiple factors, such as body composition. It is understandable to think that, due to the physical demands and specific functions during play, body composition may vary depending on the playing position. The aim of this systematic review and meta-analysis was to describe the anthropometric, BC, and somatotype characteristics of professional MSPs and to compare the reported values according to playing position. We systematically searched Embase, PubMed, SPORTDiscus, and Web of Science following the PRISMA statement. Random-effects meta-analysis, a pooled summary of means, and 95% CI (method or equation) were calculated. Random models were used with the Restricted Maximum Likelihood (REML) method. Twenty-six articles were included in the systematic review and the meta-analysis. After comparing the groups according to the playing position (goalkeeper, defender, midfielder, and forward), significant differences were found in age, height, weight, the sum of skinfolds, kilograms of muscle mass, and kilograms of fat-free mass (p = 0.001; p < 0.0001). No significant differences were observed in fat mass, percentage of fat-free mass, percentage of muscle mass, bone mass, and somatotype. Despite the limitations, this study provides useful information to help medical–technical staff to properly assess the BC of professional MSPs, providing reference values for the different positions.