Nowadays, agriculture must satisfy the growing demand for food, and increasing its sustainability, from an environmental, economic, and social point of view, is the only way to achieve this. The objective of this study was to increase the water and nutrient use efficiency of a melon crop during two consecutive seasons under commercial conditions, growing under semi-arid area. For this purpose, two treatments were studied: (i) a farmer treatment (FRM), fertigated at ~100% of crop evapotranspiration (ETc) during the whole growing season; and (ii) a precision irrigation treatment (PI), irrigated by adjusting, between flowering and ripening, the weekly farmer irrigation to minimize the leaching below the root system. The threshold for allowable soil water depletion in the active root uptake zone was set at 20–30%. The cumulative water savings in each year relative to the FRM treatment ranged between 30 and 27% for 2020 and 2021, respectively. Yield was not negatively affected, with no differences in fruit load (fruit per m) or fruit weight (kg) between irrigation treatments, although higher yields were obtained in the second year due to seasonal changes. The crop water status indicators evaluated (stem water potential, net photosynthesis, and stomatal conductance) were not affected by the irrigation treatments. Water and nitrogen productivity, on average, increased by 45.5 and 54.4% during the experimental period, respectively; the average PI ascorbic acid content increased by 33.4%.