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Royal Society of Chemistry, RSC Advances, 47(13), p. 33080-33095, 2023

DOI: 10.1039/d3ra06189b

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Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

Journal article published in 2023 by Manar G. Salem ORCID, Sara A. Abu El-Ata, Elsherbiny H. Elsayed, Suraj N. Mali ORCID, Hussah Abdullah Alshwyeh, Ghassan Almaimani, Riyad A. Almaimani ORCID, Hussain A. Almasmoum, Najla Altwaijry ORCID, Ebtesam Al-Olayan, Essa M. Saied ORCID, Mohamed F. Youssef ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We reported a novel 2-coumarin-substituted-quinoxaline analogue (3b) with potential antiproliferative activity against MCF-7 breast cancer cells by inducing cell cycle arrest and targeting topoisomerase II, and EGFR activity.